Model No:CEI-EPM-SL-45
The Elevated Plus Maze is a well-established and widely used apparatus in behavioral neuroscience research, specifically for studying anxiety-like behaviors and assessing the effects of various interventions on these behaviors in laboratory animals, particularly rodents. This maze consists of a plus-shaped platform elevated above the ground, with two opposing arms enclosed by walls and two open arms without walls. The EPM provides a controlled environment to observe and measure the natural aversion of rodents to open and elevated spaces, making it a valuable tool in preclinical research. The maze is elevated several feet above the ground, creating an aversive situation for animals. These arms have high walls on the sides, creating a confined and sheltered space. These arms have no walls or barriers, exposing animals to open and elevated spaces. Elevated Plus Maze is a valuable tool in behavioral neuroscience research for investigating anxiety-like behaviors and related phenomena in laboratory animals. Its controlled environment and quantifiable metrics make it an essential apparatus for understanding the neural and behavioral basis of anxiety and evaluating potential interventions.
Elevated plus Maze test is one of the most simple and widely used apparatus to study anxiety and anxiolytic response of almost all type of anti-anxiety agents on small rodents.
Exposure of the animals to novel maze alley evokes an approach-avoidance conflict which is stronger in open arm as compared to enclosed arm. It is based upon rodents (rats and mice) natural aversion for high and open space and prefer enclosed arm and, therefore, spend greater amount of time in enclosed arm.
When animals enter open arm, they freeze, become immobile, defecate and show fear-like movements.
The plasma cortical level is also reported to be increased, as a true reflection of anxiety.
Major advantages of this test procedure are
It is simple, fast and less time consuming,
No prior training or noxious stimuli (sound or light) is required.
It is predictable and reliable procedure for studying anxiety response as well as antianxiety of drugs.
ELEVATED PLUS MAZE is
Anxiety testing system for rats & mice.
Four arms are arranged in the shape of a cross.
Two arms have side walls and an end wall (“Closed arms”). The two other arms have no walls (“Open arms”).
Closed arm walls can be individually inserted into guide rails.
TheOpen arms are surrounded by small ledges to prevent the animal from falling from the maze.
The maze is fastened to a light weight support frame.
Four Infra red sensor and transmitters are fitted in each arm to monitor the entry and exit of the animal.
The centre part of the maze is designed in such manner that whenever animal is placed on the centre table, time gets registered.
Provided with a Control Box to monitor the activities.
Entries in the arms are registered when mice come out.
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